A vital process in maintaining a low genetic error rate is the removal of mismatched bases in DNA. The importance of this process in E. coli is demonstrated by the 100–1000 fold increase in mutation frequency observed in cells deficient in this repair system(1). Mismatches can arise as a consequence of recombination, errors in replication and as a result of spontaneous chemical deamination, the latter process resulting in an estimated twelve T:G mismatches per genome per day in mammalian cells(2). Recent (...) studies, discussed here, provide evidence for the existence of specific mismatch repair systems in mammalian and human cells. (shrink)

This volumes argues that it is essential for political theorists to think carefully about the political circumstances of indigenous groups facing persistent injustice, and about the political methods that these groups may adopt in seeking to improve their condition, particularly focusing on indigenous communitities in the US and Canada.

Much controversy has existed over the claims of Native Americans and other indigenous peoples that they have a right—based on original occupancy of land, historical transfers of sovereignty, and principles of self-determination—to a political status separate from the states in which they now find themselves embedded. How valid are these claims on moral grounds? -/- Burke Hendrix tackles these thorny questions in this book. Rather than focusing on the legal and constitutional status of indigenous nations within the states now (...) ruling them, he starts at a more basic level, interrogating fundamental justifications for political authority itself. He shows that historical claims of land ownership and prior sovereignty cannot provide a sufficient basis for challenging the authority of existing states, but that our natural moral duties to aid other persons in danger can justify rights to political separation from states that fail to protect their citizens as they should. -/- Actual attempts at political separation must be carefully managed through well-defined procedural mechanisms, however, to foster extensive democratic deliberation about the nature of the political changes at stake. Using such procedures, Hendrix argues, indigenous peoples should be able to withdraw politically from the states currently ruling them, even to the point of choosing full independence. (shrink)

The last decade has seen a slow but steady increase in the number of postdoctoral scholars employed in faculties of education. In this article, seven postdoctoral scholars who worked in the same Ca...

This essay considers the relationship between ideal theory and non-ideal theory. It begins with Rawls’s conception of ideal theory and A. John Simmons’s articulation of non-ideal theory. Both defend the priority of ideal theory over non-ideal theory. The essay then considers three different conceptions of the social barriers standing in the way of an ideal society, taken broadly from Mill, Marx, and Foucault. Each conception of power suggests a divergent strategy for pursuing non-ideal theory. The Foucauldian conception also suggests reasons (...) to mistrust our own political and moral judgments. The essay advocates a more limited view of the relationship between ideal and non-ideal theory than is commonly described, in which ideal theory retains its logical priority but not its temporal priority. In other words, the essay argues that we will fare best when we focus first on reducing specific injustices while setting aside further speculation about the character of an ideal society. (shrink)

What is the appropriate degree of abstraction from existing social facts when engaging in normative political theory? Through a focus on American Indian and other indigenous claims over historically expropriated lands, this essay argues that highly abstracted forms of normative analysis can often misunderstand the core moral problems at stake in real cases, and that they can pose moral dangers when they do so. As argued, the hard moral issues involved in indigenous land claims within countries such as Canada and (...) the United States often have far more to do with questions about competing uses for public lands than with abstract property theory as such. The essay argues that normative theorists will often do more social good, and pose fewer dangers, when they pay close attention to the real moral challenges that social actors face on the ground than when they become captured by abstract questions with ambiguous practical importance. (shrink)

While claims for the return of expropriated land by Native Americans and other indigenous peoples are often evaluated using legal frameworks, such approaches fail to engage the fundamental moral questions involved. This essay outlines three justifications for Native Americans to pursue land claims: to regain properties where original ownership has not been superseded, to aid the long-term survival of their endangered cultures, and to challenge and revise the historical misremembering of mainstream American society. The third justification is most controversial. It (...) asserts that understandings of history shape perceptions of the present, and that intensively pursued land claims can provide powerful challenges to inaccurate conceptions of the past. This essay argues that Native Americans are for this reason justified in strategically pursuing land claims that are difficult to justify on other grounds, and closes with some worries about the legitimate role of strategy in political action. (shrink)

Jeremy Waldron argues that the historical ownership rights of Aboriginal peoples can be superseded, yet acknowledges that programs of historically grounded compensation are justifiable in the absence of widespread redistribution. This article argues that existing states lack social justice programs of the requisite kind, and that they will continue to do so in the foreseeable future. Moreover, even the best-designed programs will be far more ambiguous than Waldron encourages us to recognize, given the unavoidability of inheritance-based inequalities. The article argues (...) that philosophers should pay special attention to political context when evaluating the claims of socially vulnerable populations such as Aboriginal peoples. (shrink)

This article offers a novel, conservative account of material constitution, one that incorporates sortal essentialism and features a theory of dominant sortals. It avoids coinciding objects, temporal parts, relativizations of identity, mereological essentialism, anti-essentialism, denials of the reality of the objects of our ordinary ontology, and other departures from the metaphysic implicit in ordinary ways of thinking. Defenses of the account against important objections are found in Burke 1997, 2003, and 2004, as well as in the often neglected six (...) paragraphs that conclude section V of this article. (shrink)

Jeremy Waldron has plausibly argued that historical injustices can be superseded by serious efforts to achieve justice in the present and future. This essay considers what it might mean to arrange things justly in the relevant way, focusing on the work of John Rawls as our best existing template for conceptualizing justice of this kind. The essay outlines ways in which a Rawlsian system of social justice seems unable to meet its own normative aspirations and unable to provide a model (...) for overcoming historically constituted disadvantage. As the essay argues, the society described by Rawls is likely to remain divided by inherited class structures, given the motivational requirements of markets and the psychological effects of the division of labor, so that inheritors of historical injustice would remain disadvantaged even if Rawlsian principles were put into practice. The essay considers some speculative methods for overcoming these inequalities, and argues that the most promising approach in circumstances as we know them will draw on already-existing programs of compensation for historical expropriation. The essay also argues that Rawlsians should take seriously the application of the difference principle to the distribution of political authority alongside material resources, suggesting that we should give careful thought to how political structures can protect the interests of the least advantaged. The paper argues that, once again, existing mechanisms for Aboriginal self-governance are more appropriate as a system of forward-looking justice than they may otherwise appear. The essay argues in closing that political philosophy should give increased attention to the ethics of political action and to conflict among the disadvantaged in imperfect circumstances. (shrink)

This paper reviews the literature on the mentoring process in organizations and why mentoring can be critical to the career success of women managers and professionals. It examines some of the reasons why it is more difficult for women to find mentors than it is for men. Particular attention is paid to potential problems in cross-gender mentoring. A feminist perspective is then applied to the general notion of mentorships for women. The paper concludes with an examination of what organizations can (...) do to further mentor relationships and an agenda for further research in this area. (shrink)

'One of the greatest essays ever written on art.' - The Guardian Edmund Burke’s Philosophical Enquiry into the Origin of our Ideas of the Sublime and Beautiful is one of the most important works of aesthetics ever written. Whilst many writers have taken up their pen to write of ‘the beautiful’, Burke’s subject here was that quality he uniquely distinguished as ‘the sublime’ – an all-consuming force beyond beauty that compelled terror as much as rapture in all who (...) beheld it. It was an analysis that would go on to inspire some of the leading thinkers of the Enlightenment, including Immanuel Kant and Denis Diderot. The Routledge Classics edition presents the authoritative text of the first critical edition of Burke’s essay ever published, including a substantial critical and historical commentary. (shrink)

Defenders of Aboriginal rights such as James Tully have argued that members of majority populations should allow Aboriginal peoples to argue within their own preferred intellectual frameworks in seeking common moral ground. But how should non-Aboriginal academics react to claims that seem insufficiently critical or even incoherent? This essay argues that there are two reasons to be especially wary of attacking such errors given the historical injustices perpetrated by settler states against Aboriginal peoples. First, attempts to root out error will (...) often be misplaced, because they will fail to consider the full range of possible reasons for particular kinds of social practices. Second, such attempts will often have counterproductive social effects in disrupting conversations and prolonging Aboriginal alienation. This essay thus argues that non-Aboriginal academics should be willing to exercise considerable self-restraint toward apparent intellectual errors, because such a strategy will be most conducive to realizing justice over the long term. (shrink)

As critic, Kenneth Burke's preoccupations were at the beginning purely esthetic and literary; but afterCounter-Statement(1931), he began to discriminate a ...

El objetivo de este artículo es proponer una justificación lógica del proceso de razonamiento sustitutivo en la práctica del modelado en ciencia. Para ello, definimos la generación de hipótesis como la creación de un diálogo interactivo y formal entre el modelo y el sistema objetivo. Para describir esta idea desde un punto de vista lógico, nos basaremos en el enfoque pragmático de la Dialógica como marco ideal para ilustrar las interacciones lógicas.

I describe a “logic of creating” inspired by the “existential” argument of the existence of God in St. Thomas Aquinas’s De Ente et Essentia. suggest a modal reading of his reasoning based upon states-of-affairs said to be actual, contingent, necessary and the like. I take “creating” as teasing actuality out of possibility. After explaining the modal logic that I am assuming and relating it to Christian understandings of meaning and being, I present my modal interpretation, contrasting it with the views (...) of three modern philosophers. In an appendix I will analyze the text of St. Thomas’s existential proof. (shrink)

This article aims to present a Free Dialogic Logic [FDL] as a general framework for hypothesis generation in the practice of modelling in science. Our proposal is based on the idea that the inferential function that models fulfil during the modelling process (surrogate reasoning) should be carried out without ontological commitments. The starting point to achieve our objective is that the scientific consideration of models without a target is a symptom that, on the one hand, the Applicability of Logic should (...) be considered among the conditions of adequacy that should take into account all modeling process and, on the other, that the inferential apparatus at the base of the surrogate reasoning process must be rid of realistic assumptions that lead to erroneous conclusions. In this sense, we propose as an alternative an ontologically neutral inferential system in the perspective of dialogical pragmatism. (shrink)

In September 2008, 10 years after the untimely death of Pere Alberch (1954–1998), the 20th Altenberg Workshop in Theoretical Biology gathered a group of Pere’s students, col- laborators, and colleagues (Figure 1) to celebrate his contribu- tions to the origins of EvoDevo. Hosted by the Konrad Lorenz Institute for Evolution and Cognition Research (KLI) outside Vienna, the group met for two days of discussion. The meeting was organized in tandem with a congress held in May 2008 at the Cavanilles Institute (...) for Biodiversity and Evolutionary Biology (ICBiBE) in Valencia, Spain. The talks at the KLI were equal parts: nostalgic remembrance, excitement over new ways of thinking about old problems, and an unrepressed vitriol against the resurgence of reductionist thinking in EvoDevo. Here we highlight some of the key aspects of Pere’s life and work that informed and infused the talks. (shrink)

Redmond and Smith reveal how the development of a continent-wide advance warning system against attack by missiles and manned aircraft set the stage for 1960's computing development. SAGE's design introduced concepts related to mass data processing that would later make personal and business computing a reality.

INTRODUCTION In an age of specialists, Kenneth Burke's writings offend those who are content with a partial view of human motivation. ...

This paper argues that professionals who make boundary-related decisions should be guided by relationship-based practice. In our roles as service users and professionals, drawing from our lived experiences of professional relationships, we argue we need to move away from distance-based practice. This includes understanding the boundary stories and narratives that exist for all of us – including the people we support, other professionals, as well as the organisations and systems within which we work. When we are dealing with professional boundary (...) issues, we should centre relationship-building skills that are central to many other aspects of our work. Skills that foster relationships at all levels – between professionals, service users, and services – need to be revalued. Our final recommendation is to create, develop, and foster safer spaces within and outside of organisations, as well as inter-professionally, for the discussion and exploration of boundary-related issues and practice. We are interested in hearing from those with experiences of being marginalised by boundaries so that they can inform a reshaping of our collective ideas around boundary related practices. To foster relationship-based practices in organisations, we have outlined several recommendations here; however, we recognize that these do not go far enough, and that collective action is needed to inform systemic change. (shrink)

This, the last volume in the series, provides the keys to all the others. All letters to and from Burke are listed, and the material in the letters themselves analysed in a comprehensive general index.

This selection from his speeches and writings reveals a political philosophy which is viable. even prophetic, in our own time. Burke's distrust of disembodied reason, his vision of the law of all nations, and his wide pragmatism speak to everyone concerned with maintaining the democratic freedoms in an age when millions are subject to the tyranny of abstract political ideas. -- back cover.

Este libro es parte de la colección e-Libro en BiblioBoard.

In this paper, I offer a novel, conservative solution to the puzzle of Tibbles the cat. I do not criticize the existing solutions or the theories within which they are embedded. I am content to offer an alternative, one that relies on the recently resurgent doctrine of Aristotelian essentialism. My solution, unlike some of its competitors, is applicable to the full range of cases in which, as with Tib and Tibbles, there is the threat of coinciding objects. In section 1, (...) I present the solution. In sections II-IV, I defend it against four objections. (shrink)

An eloquent and sometimes even erotic book, the Philosophical Enquiry was long dismissed as a piece of mere juvenilia. However, Burke's analysis of the relationship between emotion, beauty, and art form is now recognized as not only an important and influential work of aesthetic theory, but also one of the first major works in European literature on the Sublime, a subject that has fascinated thinkers from Kant and Coleridge to the philosophers and critics of today. This is the only (...) available edition of the work. ABOUT THE SERIES: For over 100 years Oxford World's Classics has made available the widest range of literature from around the globe. Each affordable volume reflects Oxford's commitment to scholarship, providing the most accurate text plus a wealth of other valuable features, including expert introductions by leading authorities, helpful notes to clarify the text, up-to-date bibliographies for further study, and much more. (shrink)

Dion is a full-bodied man. Theon is that part of him which consists of all of him except his left foot. What becomes of Dion and Theon when Dion’s left foot is amputated? Employing the doctrine of sortal essentialism, I defend a surprising answer last defended by Chrysippus: that Dion survives while the seemingly unscathed Theon perishes. For replies to critics, see my publications of 1997 and (especially) 2003.